Al Ozonoff

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Articles

Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients - Nature Communications

Jan 10, 2025 | nature.com | Cole Maguire |Nadine Rouphael |William Messer |Matthew Altman |Patrice Becker |Steven E. Bosinger | +9 more

AbstractCoronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls.
Features of Acute COVID-19 Associated With Post-acute Sequelae of SARS-CoV-2 Phenotypes: Results From the IMPACC Study

Jan 7, 2025 | digitalcommons.library.tmc.edu | Al Ozonoff |Naresh Doni Jayavelu |Shanshan Liu |Esther Melamed

KeywordsFemale, Humans, SARS-CoV-2, COVID-19, B-Lymphocytes, Body Fluids, Disease Progression, PhenotypeAbstractPost-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge.
Red tape strangles viral surveillance programs

Dec 19, 2024 | science.org | Al Ozonoff |Annie Elong Ngono |Robert Frederick

Information & AuthorsPublished In ScienceVolume 386 | Issue 672820 December 2024Article versionsSubmission historyPublished in print: 20 December 2024PermissionsRequest permissions for this article. Metrics & Citations Article Usage Altmetrics Cite as Red tape strangles viral surveillance programs.Science386,1357-1357(2024).DOI:10.1126/science.ads3461 Export citation Select the format you want to export the citation of this publication.
Red tape strangles viral surveillance programs

Dec 19, 2024 | science.org | Al Ozonoff |Annie Elong Ngono |Robert Frederick

Information & AuthorsPublished In ScienceVolume 386 | Issue 672820 December 2024Article versionsSubmission historyPublished in print: 20 December 2024PermissionsRequest permissions for this article. Metrics & Citations Article Usage Altmetrics Cite as Red tape strangles viral surveillance programs.Science386,1357-1357(2024).DOI:10.1126/science.ads3461 Export citation Select the format you want to export the citation of this publication.
DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life - Nature Communications

Sep 16, 2024 | nature.com | David Martino |Casey P. Shannon |Bhavjinder K Dhillon |Joann Diray-Arce |Al Ozonoff |Kinga K. Smolen | +4 more

AbstractUnderstanding of newborn immune ontogeny in the first week of life will enable age-appropriate strategies for safeguarding vulnerable newborns against infectious diseases. Here we conducted an observational study exploring the immunological profile of infants longitudinally throughout their first week of life.
The next pandemic virus could be built using AI

Sep 16, 2024 | thehill.com | Arya S. Rao |Al Ozonoff |Pardis Sabeti

Almost five years after the COVID-19 pandemic began, its central question remains subject to heated debate: Did the SARS-CoV-2 virus originate naturally, or was it leaked from a scientific lab participating in gain-of-function research? This controversy has sparked vitriol from all sides, as politicians and scientists battle publicly over the contents of data from the Wuhan market and the role of NIH-funded research.
Increased pediatric RSV case counts following the emergence of SARS-CoV-2 are attributable to increased testing

Feb 6, 2024 | medrxiv.org | Brittany A. Petros |Carly E. Milliren |Pardis Sabeti |Al Ozonoff

PCS is a co-founder of, shareholder in, and advisor to Sherlock Biosciences, Inc.; a board member of and shareholder in the Danaher Corporation; a co-founder of and shareholder in Delve Bio; and a shareholder in NextGenJane and TruGenomix.
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice - npj Vaccines

Feb 14, 2023 | nature.com | Etsuro Nanishi |Hyuk-Soo Seo |Kijun Song |Andrew Xu |Soumik Barman |Blake M Hauser | +8 more

AbstractDevelopment of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies and protection in young and aged mice. While demonstrating superior immunogenicity to soluble receptor-binding domain (RBD), RBD displayed as a protein nanoparticle (RBD-NP) generated limited antibody responses.

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Al Ozonoff

Articles

Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients - Nature Communications

Features of Acute COVID-19 Associated With Post-acute Sequelae of SARS-CoV-2 Phenotypes: Results From the IMPACC Study

Red tape strangles viral surveillance programs

Red tape strangles viral surveillance programs

DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life - Nature Communications

The next pandemic virus could be built using AI

Increased pediatric RSV case counts following the emergence of SARS-CoV-2 are attributable to increased testing

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice - npj Vaccines

Contact details

Emails

Socials & Sites