Alan Simmons

2 weeks ago | biorxiv.org | Mirazul Islam |Matthew Bechard |Yilin Yang |Alan Simmons

AbstractThe mammalian intestine regenerates rapidly after damage, yet the clonal dynamics and species-specific regulation of different populations remain poorly understood. Here we used synthetic or naturally occurring DNA alterations to reconstruct clonal histories of the mouse and human intestinal epithelium at single-cell resolution. In mice, we uncovered the clonal architecture of different cell types and their roles in regeneration, supporting a hierarchical regenerative response model.