Alberto Hipólito

Oct 24, 2024 | nature.com | André Carvalho |Alberto Hipólito

AbstractIntegrons are key elements in the rise and spread of multidrug resistance in Gram-negative bacteria. These genetic platforms capture cassettes containing promoterless genes and stockpile them in arrays of variable length. In the current integron model, expression of cassettes is granted by the Pc promoter in the platform and is assumed to decrease as a function of its distance.

Mar 26, 2024 | biorxiv.org | André Carvalho |Alberto Hipólito |Lucia Garcia-Pastor |Ester Vergara

AbstractIntegrons are key elements in the rise and spread of multidrug resistance in Gram-negative bacteria. These genetic platforms capture cassettes containing promoterless genes and stockpile them in arrays of variable length. In the current integron model, expression of cassettes is granted by the Pc promoter in the platform and is assumed to decrease as a function of its distance.

Oct 11, 2023 | nature.com | Lucia Garcia-Pastor |Alberto Hipólito |Ester Vergara

AbstractIntegrons have played a major role in the rise and spread of multidrug resistance in Gram-negative pathogens and are nowadays commonplace among clinical isolates. These platforms capture, stockpile, and modulate the expression of more than 170 antimicrobial resistance cassettes (ARCs) against most clinically-relevant antibiotics.