Alberto Picchi

Jan 8, 2025 | sciencedirect.com | Alberto Picchi |Andrea Pucci |Ilya V. Nechaev |Georgij V. Cherkaev

Quinoline and its derivatives, as an important class of compounds and skeletons, have been widely used in pharmaceuticals, herbicides, dyes, etc., such as Montelukast, Quinine, Bedaquiline and Chloroquine (Fig. 1) [1]. In the past few decades, to enrich such quinoline skeletons, innumerable classical strategies have been reported, such as the Skraup reaction [2], Doebner−Miller reaction [3], Friedlander reaction [4] and Povarov reaction [5].