Alejandro Minguez Sabater

Sep 5, 2024 | sciencedirect.com | Alejandro Minguez Sabater |Marina Berenguer |Shivani Bisen |Allan Massie

Parkinson’s disease (PD) is the second most common neurodegenerative disease and is a representative disease with aggregated α-Synuclein (α-Syn) inclusions in the brain, also called synucleinopathies.1 α-Syn aggregation appears in the substantia nigra (SN) and triggers dopaminergic neuronal death, which is a pathological hallmark of PD. However, α-Syn aggregates can be detected in the gastrointestinal (GI) tract much earlier than in the brain.2,3 Braak et al.