Shivani Bisen

Sep 5, 2024 | sciencedirect.com | Alejandro Minguez Sabater |Marina Berenguer |Shivani Bisen |Allan Massie

Parkinson’s disease (PD) is the second most common neurodegenerative disease and is a representative disease with aggregated α-Synuclein (α-Syn) inclusions in the brain, also called synucleinopathies.1 α-Syn aggregation appears in the substantia nigra (SN) and triggers dopaminergic neuronal death, which is a pathological hallmark of PD. However, α-Syn aggregates can be detected in the gastrointestinal (GI) tract much earlier than in the brain.2,3 Braak et al.

Jul 24, 2023 | nature.com | Nader Moazami |Karen Abou Khalil |Jacqueline Kim |Shivani Bisen |Ian Jaffe |Maria Kokkinaki | +3 more

AbstractGenetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart has been implanted into only one human recipient. Here, using 10-gene-edited pigs, we transplanted porcine hearts into two brain-dead human recipients and monitored xenograft function, hemodynamics and systemic responses over the course of 66 hours.