Alessandro Borsellini

May 3, 2024 | biorxiv.org | Alessandro Borsellini |Duccio Conti |Erin E. Cutts |Rebecca Harris

AbstractCondensin complexes promote the drastic spatial rearrangement of the genome upon mitotic entry. Condensin II initiates chromosome condensation in early mitosis. To prevent chromosome condensation during interphase, condensin II is inhibited by MCPH1, but the mechanism is unknown. Through genetic and proteomic approaches, we identify M18BP1, a protein previously associated with centromere identity, as a factor required for condensin II localization to chromatin.