Duccio Conti

Sep 5, 2024 | science.org | Eyal G. Frank |Sam Lee |Laksshman Sundaram |Duccio Conti

Editor’s summarySuccessful cell division requires precise separation of chromosomes with near perfect fidelity to the daughter cells. Central to this essential process is attachment of the chromosomal centromeres to microtubules of the mitotic spindle. After DNA replication, properly timed regeneration of the centromere and its associated protein complex is essential. Conti et al. and Parashara et al. reveal how Polo-like kinase 1 (PLK-1) coordinates this process at the end of mitosis.

May 3, 2024 | biorxiv.org | Alessandro Borsellini |Duccio Conti |Erin E. Cutts |Rebecca Harris

AbstractCondensin complexes promote the drastic spatial rearrangement of the genome upon mitotic entry. Condensin II initiates chromosome condensation in early mitosis. To prevent chromosome condensation during interphase, condensin II is inhibited by MCPH1, but the mechanism is unknown. Through genetic and proteomic approaches, we identify M18BP1, a protein previously associated with centromere identity, as a factor required for condensin II localization to chromatin.