Alex Cagan

Cambridge

Contributor at Freelance

Researching somatic evolution at the University of Cambridge and Wellcome Sanger Institute. Also a scientific illustrator.

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Articles

Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature

Mar 5, 2025 | nature.com | Chiraag Kapadia |Nicholas Williams |Caroline Watson |Matthew J. Yousefzadeh |Kudzai Nyamondo |Alex Cagan | +8 more

AbstractHaematopoietic stem cells maintain blood production throughout life1. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies.
Drawn to Life

Feb 1, 2025 | alexcagan.substack.com | Alex Cagan

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