Kudzai Nyamondo

Mar 5, 2025 | nature.com | Chiraag Kapadia |Nicholas Williams |Caroline Watson |Matthew J. Yousefzadeh |Kudzai Nyamondo |Alex Cagan | +8 more

AbstractHaematopoietic stem cells maintain blood production throughout life1. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies.