Alexa Osterhoudt

Dec 20, 2023 | nature.com | Andrea M. Chiariello |Rachel Duffié |Kevin Monahan |Alexa Osterhoudt |Job Dekker |Mario Nicodemi

AbstractOlfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one of approximately 2,000 or more OR alleles1,2. OR gene choice is mediated by a multichromosomal enhancer hub that activates transcription at a single OR3,4, followed by OR-translation-dependent feedback that stabilizes this choice5,6.