Job Dekker

Feb 22, 2024 | nature.com | Jake Lee |Doga C. Gulhan |Sergey V. Venev |Eric Wooten |Kamila Naxerova |Job Dekker | +1 more

AbstractWhole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly understood. Here, utilizing unbiased whole chromosome genetic screens combined with in vitro evolution to generate arm- and subarm-level events, we iteratively selected the fittest karyotypes from aneuploidized human renal and mammary epithelial cells.

Dec 20, 2023 | nature.com | Andrea M. Chiariello |Rachel Duffié |Kevin Monahan |Alexa Osterhoudt |Job Dekker |Mario Nicodemi

AbstractOlfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one of approximately 2,000 or more OR alleles1,2. OR gene choice is mediated by a multichromosomal enhancer hub that activates transcription at a single OR3,4, followed by OR-translation-dependent feedback that stabilizes this choice5,6.