Alexander Brown

1 month ago | biorxiv.org | Aryaman Sharma |Lauren Ellis |Alexander Brown |Kaytlin Andrews

AbstractMedulloblastoma (MB), the most common malignant pediatric brain tumor, remains difficult to cure upon relapse, with only 12.4% of patients surviving five years post-recurrence. While specific quiescent tumor cell populations are known to contribute to treatment-resistance, the molecular mechanisms that maintain quiescence remain poorly defined. Here, we identify the cell cycle inhibitor p57 as a regulator of quiescence and chemotherapy resistance in Sonic Hedgehog (SHH) MB.

Oct 25, 2023 | nature.com | Andrew J. Levan |Benjamin P. Gompertz |Eric Burns |Luca Izzo |Gavin Lamb |Daniele B. Malesani | +43 more

AbstractThe mergers of binary compact objects such as neutron stars and black holes are of central interest to several areas of astrophysics, including as the progenitors of gamma-ray bursts (GRBs)1, sources of high-frequency gravitational waves (GW)2 and likely production sites for heavy element nucleosynthesis via rapid neutron capture (the r-process)3. Here we present observations of the exceptionally bright gamma-ray burst GRB 230307A.