Lauren Ellis

1 month ago | biorxiv.org | Aryaman Sharma |Lauren Ellis |Alexander Brown |Kaytlin Andrews

AbstractMedulloblastoma (MB), the most common malignant pediatric brain tumor, remains difficult to cure upon relapse, with only 12.4% of patients surviving five years post-recurrence. While specific quiescent tumor cell populations are known to contribute to treatment-resistance, the molecular mechanisms that maintain quiescence remain poorly defined. Here, we identify the cell cycle inhibitor p57 as a regulator of quiescence and chemotherapy resistance in Sonic Hedgehog (SHH) MB.

Jan 19, 2025 | jbc.org | Simone Hall |Jonathan Zhu |Lauren Ellis

KeywordsLong non-coding RNAmRNARNA binding proteinRNA-protein interactionmRNA stabilitygene expressionMALAT1TAR DNA-binding protein 43 (TDP-43) (TARDBP)neurodegenerationIntroductionRNA-protein interactions regulate gene expression, splicing, and cell growth. Genome-wide studies of RNA-protein interactions suggest that eukaryotic cells contain complex networks of binding interactions between RNAs and proteins, including mRNAs, non-coding RNAs, splicing factors and other RNA binding proteins.

Jul 14, 2023 | charlestoncountydevelopment.org | Lauren Ellis

July 14, 2023 Jay Kramer has been selected as a 2023 Forty Under 40 winner by the Charleston Regional Business Journal, nominated by members of the Charleston community. Since 1998, this elite 40 has been comprised of people under 40 years of age who have excelled in the professional arena and in community involvement. We continue to be amazed at the number of individuals who are nominated each year and the quality work and commitment they bring to the Charleston community.