Alexander C. Bashore

Oct 4, 2024 | biorxiv.org | Allen Chung |Hyun Chang |Huize Pan |Alexander C. Bashore

AbstractHuman genetic studies have repeatedly associated ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic and induced in response to vascular injury and that the proatherogenicity of ADAMTS7, a secreted protein, is due to its catalytic activity. However, the cell-specific mechanisms governing ADAMTS7 proatherogenicity remain unclear.

Feb 29, 2024 | biorxiv.org | Allen Chung |Hyun Chang |Huize Pan |Alexander C. Bashore

AbstractHuman genetic studies have repeatedly associated SNPs near the gene ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic, induced in response to vascular injury, and alters smooth muscle cell function. However, the mechanisms governing this function and its relationship to atherosclerosis remain unclear.

Sep 29, 2023 | biorxiv.org | Alexander C. Bashore |Allen Chung |Hanying Yan |Chinyere Ibikunle

AbstractVascular smooth muscle cells (VSMCs) play a central role in the development of atherosclerosis due in part to their capability to phenotypically transition into either a protective or harmful state. However, the ability to identify and trace VSMCs and their progeny in vivo is limited due to the lack of well-defined VSMC cell surface markers.