Hanying Yan

Jan 24, 2025 | nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Isabel Barnfather |Joshua D. Rabinowitz |Yanxiang Deng | +5 more

Correction to: Nature Methods https://doi.org/10.1038/s41592-024-02574-2, published online 15 January 2025. In the version of the article initially published, the Data availability and Code availability sections were inadvertently omitted. These sections have now been included in the HTML and PDF versions of the article. About this articleColeman, K., Schroeder, A., Loth, M. et al. Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO. Nat Methods (2025).

Jan 15, 2025 | nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Joshua D. Rabinowitz |Yanxiang Deng |Edward Lee | +5 more

AbstractSpatial molecular profiling has provided biomedical researchers valuable opportunities to better understand the relationship between cellular localization and tissue function. Effectively modeling multimodal spatial omics data is crucial for understanding tissue complexity and underlying biology.

Nov 4, 2024 | nature.com | Huasheng Yu |Saad S. Nagi |Dmitry Usoskin |Yizhou Hu |Otmane Bouchatta |Hanying Yan | +10 more

AbstractThe versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human (h)DRG neurons—critical information to decipher their functions—are lacking due to technical difficulties. In this study, we isolated somata from individual hDRG neurons and conducted deep RNA sequencing (RNA-seq) to detect, on average, over 9,000 unique genes per neuron, and we identified 16 neuronal types.

Sep 29, 2023 | biorxiv.org | Alexander C. Bashore |Allen Chung |Hanying Yan |Chinyere Ibikunle

AbstractVascular smooth muscle cells (VSMCs) play a central role in the development of atherosclerosis due in part to their capability to phenotypically transition into either a protective or harmful state. However, the ability to identify and trace VSMCs and their progeny in vivo is limited due to the lack of well-defined VSMC cell surface markers.