Alexander Drzezga

May 1, 2024 | nature.com | Alexander Drzezga |Verena Dzialas

AbstractResilience in neuroscience generally refers to an individual’s capacity to counteract the adverse effects of a neuropathological condition. While resilience mechanisms in Alzheimer’s disease are well-investigated, knowledge regarding its quantification, neurobiological underpinnings, network adaptations, and long-term effects in Parkinson’s disease is limited.

May 1, 2024 | flipboard.com | Verena Dzialas |Merle C. Hoenig |Stéphane Prange |Gérard N Bischof |Alexander Drzezga |Thilo van Eimeren

Structural underpinnings and long-term effects of resilience in Parkinson’s diseaseResilience in neuroscience generally refers to an individual’s capacity to counteract the adverse effects of a neuropathological condition. While …

Feb 28, 2024 | nature.com | Alexander Drzezga |Ali Gordji-Nejad |Andreas Matusch |Andreas Bauer |David Elmenhorst |Sophie Kleedörfer | +2 more

The inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation. With this, the main obstacle is the limited exogenous uptake by the central nervous system (CNS), making creatine only effective over a long-term diet of weeks. Thus far, only repeated dosing of creatine over weeks has been studied, yielding detectable changes in CNS levels. Based on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate (0.35 g/kg) while performing cognitive tests during sleep deprivation. Two consecutive 31P-MRS scans, 1H-MRS, and cognitive tests were performed each at evening baseline, 3, 5.5, and 7.5 h after single dose creatine (0.35 g/kg) or placebo during sub-total 21 h sleep deprivation (SD). Our results show that creatine induces changes in PCr/Pi, ATP, tCr/tNAA, prevents a drop in pH level, and improves cognitive performance and processing speed. These outcomes suggest that a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive deterioration.

Jan 16, 2024 | biorxiv.org | Merle C. Hoenig |Elena Doering |Gérard N Bischof |Alexander Drzezga

AbstractIntroduction: Consistent with the amyloid-cascade-hypothesis, we tested whether regional amyloid burden is associated with tau pathology increases in spatially independent brain regions and whether functional connectivity serves as a mediator bridging the observed spatial gap between these pathologies. Methods: Data of 98 amyloid-positive and 35 amyloid-negative subjects with baseline amyloid (18F-AV45) and longitudinal tau (18F-AV1451) PET were selected from ADNI.