Gérard N Bischof

Sep 3, 2024 | biorxiv.org | Merle C. Hoenig |Verena Dzialas |Elena Doering |Gérard N Bischof

AbstractObjective: To examine interactive effects of modifiable factors, genetic determinants and load-dependent pathology effects on tau pathology progression. Methods: Data of 162 amyloid-positive individuals were included, for whom longitudinal [18F]AV-1451-PET scans, baseline information on global amyloid load, ApoE4 status, body-mass-index (BMI), hypertension, education, neuropsychiatric symptom severity and demographic information were available in ADNI.

May 1, 2024 | flipboard.com | Verena Dzialas |Merle C. Hoenig |Stéphane Prange |Gérard N Bischof |Alexander Drzezga |Thilo van Eimeren

Structural underpinnings and long-term effects of resilience in Parkinson’s diseaseResilience in neuroscience generally refers to an individual’s capacity to counteract the adverse effects of a neuropathological condition. While …

Jan 16, 2024 | biorxiv.org | Merle C. Hoenig |Elena Doering |Gérard N Bischof |Alexander Drzezga

AbstractIntroduction: Consistent with the amyloid-cascade-hypothesis, we tested whether regional amyloid burden is associated with tau pathology increases in spatially independent brain regions and whether functional connectivity serves as a mediator bridging the observed spatial gap between these pathologies. Methods: Data of 98 amyloid-positive and 35 amyloid-negative subjects with baseline amyloid (18F-AV45) and longitudinal tau (18F-AV1451) PET were selected from ADNI.

Nov 27, 2023 | n.neurology.org | Hendrik Theis |Ruhr Bochum |Forschungszentrum Jülich |Gérard N Bischof

MethodsPatients had been included in the German Network for Research on Autoimmune Encephalitis (GENERATE). Initial institutional review board (IRB) approval was given by the ethical advisory board of the University of Luebeck, Germany (reference number: 13-162), and GENERATE was approved by IRBs of all actively recruiting centers. The study was performed according to the Declaration of Helsinki. Written informed consent was given before enrollment in the registry.