Alexander Nguyen

Nov 2, 2024 | nature.com | Diemmy Nguyen |Laurel Darragh |Mike W. Matsumoto |Benjamin Van Court |Alexander Nguyen |Shilpa Bhatia | +7 more

AbstractThe EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck squamous cell carcinoma (HNSCC) poses a significant challenge to rational drug design. We find that EphB4 knockdown in cancer cells enhances metastasis in preclinical HNSCC models by augmenting immunosuppressive cells like T regulatory cells (Tregs) within the tumor microenvironment.

Nov 2, 2024 | nature.com | Diemmy Nguyen |Laurel Darragh |Mike W. Matsumoto |Benjamin Van Court |Alexander Nguyen |Shilpa Bhatia | +7 more

AbstractThe EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck squamous cell carcinoma (HNSCC) poses a significant challenge to rational drug design. We find that EphB4 knockdown in cancer cells enhances metastasis in preclinical HNSCC models by augmenting immunosuppressive cells like T regulatory cells (Tregs) within the tumor microenvironment.

Oct 3, 2024 | link.springer.com | Alexander Nguyen

AbstractChromosomal replication is a ubiquitous and essential cellular process. In bacteria, the master replication initiator DnaA plays a key role in promoting an open complex at the origin (oriC) and recruiting helicase in a tightly regulated process. The C-terminal domain IV specifically recognises consensus sequences of double-stranded DNA in oriC, termed DnaA-boxes, thereby facilitating the initial engagement of DnaA to oriC.

Sep 13, 2023 | tandfonline.com | Leah Ferguson |Alexander Nguyen |Rachel Wu

Despite internet usage rates for older adults rapidly increasing (Faverio, Citation2022 (2022). January 13). Share of those 65 and older who are tech users has grown in the past decade. Pew Research Center. Retrieved February 17, 2023, from  [Google Scholar]), there remains a large divide for information technology adoption (namely for computers and tablets) between other age groups and within the older adult population.