Benjamin Van Court

Nov 2, 2024 | nature.com | Diemmy Nguyen |Laurel Darragh |Mike W. Matsumoto |Benjamin Van Court |Alexander Nguyen |Shilpa Bhatia | +7 more

AbstractThe EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck squamous cell carcinoma (HNSCC) poses a significant challenge to rational drug design. We find that EphB4 knockdown in cancer cells enhances metastasis in preclinical HNSCC models by augmenting immunosuppressive cells like T regulatory cells (Tregs) within the tumor microenvironment.

Nov 2, 2024 | nature.com | Diemmy Nguyen |Laurel Darragh |Mike W. Matsumoto |Benjamin Van Court |Alexander Nguyen |Shilpa Bhatia | +7 more

AbstractThe EphB4-ephrinB2 signaling axis has been heavily implicated in metastasis across numerous cancer types. Our emerging understanding of the dichotomous roles that EphB4 and ephrinB2 play in head and neck squamous cell carcinoma (HNSCC) poses a significant challenge to rational drug design. We find that EphB4 knockdown in cancer cells enhances metastasis in preclinical HNSCC models by augmenting immunosuppressive cells like T regulatory cells (Tregs) within the tumor microenvironment.

Sep 24, 2024 | biorxiv.org | Benjamin Van Court |Michael W. Knitz |Mark Ciccaglione |Brooke Neupert

AbstractRecently developed nanobubble ultrasound contrast agents are a promising tool for imaging and drug delivery in tumors. To better understand their unusual kinetics, we implemented a novel pixel clustering analysis, which provides unique information by accounting for spatial heterogeneity.