Alexander Teumer

Aug 15, 2024 | digitalcommons.library.tmc.edu | Mathias Gorski |Humaira Rasheed |Alexander Teumer |Laurent Thomas

AbstractEstimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability.

Apr 17, 2023 | nature.com | Marie-Gabrielle Duperron |Maria J. Knol |Quentin Le Grand |Tavia E. Evans |Ami Tsuchida |Gennady V Roshchupkin | +35 more

AbstractPerivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter.

Mar 7, 2023 | nature.com | Hongyu Zhao |Urmo Võsa |Lude Franke |Alexis Battle |Alexander Teumer |Terho Lehtimäki | +2 more

AbstractMost existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size.