Mathias Gorski

Nov 19, 2024 | nature.com | Simon Wiegrebe |Mathias Gorski |Klaus J. Stark |Christian Gieger |Johannes Schödel |Han Chen | +3 more

AbstractUnderstanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. We use longitudinal UK Biobank data for creatinine-based estimated glomerular filtration rate from 348,275 individuals to search for genetic variants associated with eGFR-decline. This search was performed both among 595 variants previously associated with eGFR in cross-sectional GWAS and genome-wide.

Aug 21, 2024 | nature.com | Julian Konzok |Mathias Gorski |Thomas Winkler |Varun Warrier

AbstractObservational studies suggest that child maltreatment increases the risk of externalizing spectrum disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), antisocial personality disorder (ASPD), and substance use disorder (SUD). Yet, only few of such associations have been investigated by approaches that provide strong evidence for causation, such as Mendelian Randomization (MR).

Aug 15, 2024 | digitalcommons.library.tmc.edu | Mathias Gorski |Humaira Rasheed |Alexander Teumer |Laurent Thomas

AbstractEstimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability.