Alexandra Hart

1 month ago | tpr.org | Alexandra Hart

It’s a well-worn piece of frugal advice for those looking to save money in times of economic hardship: Buy generic instead of name-brand groceries. But more and more, in-house brands are actually becoming part of a store’s appeal. Think Trader Joe’s or Aldi, both of which stock private label goods almost exclusively. Here in Texas, H-E-B has their extensive roster of store-brand items, some of which have quite the loyal following.

1 month ago | dentonrc.com | Alexandra Hart

Decriminalizing small amounts of marijuana has consistently appeared on local ballots across the state over the past three years. Bastrop, Lockhart and Dallas became the latest Texas cities last November to pass such measures. They joined cities like Austin, San Marcos, Killeen, Elgin, Denton and Harker Heights, which had previously passed decriminalization ordinances. However, Texas Attorney General Ken Paxton has taken issue with these local changes, arguing that they violate state law.

1 month ago | texasstandard.org | Alexandra Hart

Texas Attorney General Ken Paxton announced earlier this month that he is launching a primary challenge to Sen. John Cornyn for his seat in the U.S. Senate. Now, Texans want to know who will fill Paxton’s place as the highest legal officer of the state. One name garnering a lot of attention is Texas Sen. Mayes Middleton, a Republican from Galveston who announced his bid for attorney general earlier this week.

2 months ago | dentonrc.com | Alexandra Hart

In the wake of Texas’ 2019 hemp legalization measure, a booming industry of consumable hemp products has cropped up. It generates, by some estimates, around $8 billion a year in revenue. But Lt. Gov. Dan Patrick has made one thing clear: Consumable hemp products with psychoactive THC need to go. He’s said banning the sale of intoxicating cannabis products is one of his top legislative priorities this session. Senate Bill 3, authored by Republican Sen. Charles Perry, would do just that.

2 months ago | biorxiv.org | Jordan Wilson |Jiayi Zhu |Simon Lam |Alexandra Hart

AbstractInhibitors of the protein kinase WEE1 have emerged as promising agents for cancer therapy. In this study, we uncover synergistic interactions between WEE1 small-molecule inhibitors and defects in mRNA translation, mediated by activation of the integrated stress response (ISR) through the kinase GCN2. Using a pooled CRISPRi screen, we identify GSPT1 and ALKBH8 as factors whose depletion confer hypersensitivity to the WEE1 inhibitor, AZD1775.