Alexandra L. Tse

Nov 22, 2024 | tuftsdaily.com | Alexandra L. Tse

Staff at the Steve Tisch Sports and Fitness Center have upgraded their cleaning protocols following student concerns about “smelly” and “dangerous” weights. Disclaimer: Nina Zimmerman is a former Executive Audio Editor at The Tufts Daily. She was not involved in the writing or editing of this article.

Nov 15, 2024 | journals.plos.org | Alexandra L. Tse |Albert Einstein College |Cory M. Acreman |Inna Ricardo-Lax |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Tse AL, Acreman CM, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, et al. (2024) Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses. PLoS Pathog 20(11): e1012704. https://doi.org/10.1371/journal.ppat.1012704Editor: Jesse D.

Oct 9, 2024 | tuftsdaily.com | Alexandra L. Tse

The Tufts alum spoke about advocating for community-driven solutions to climate change during a talk on Thursday. Andrea Savage, a campaign manager for the Clean Transportation Program at the Union of Concerned Scientists and a Tufts alumna, spoke at the Hoch Cunningham Environmental Lectures series on Thursday.

Aug 26, 2024 | nature.com | Xandra Nuqui |Lorenzo Casalino |Ling Zhou |Albert Wang |Alexandra L. Tse |Surl-Hee Ahn | +1 more

AbstractThe full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodominant S1 subunit. S2, in contrast, is the most evolutionarily conserved region of the spike and can elicit broadly neutralizing and protective antibodies. Yet, S2’s usage as an alternative vaccine strategy is hampered by its general instability.

Feb 20, 2024 | nature.com | Ching-Lin Hsieh |Sarah R. Leist |John Powers |Jonathan C. Schisler |Ralph S Baric |Alexandra L. Tse

AbstractEver-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that offers a greater breadth of protection against current and future VOCs would eliminate the need to reformulate COVID-19 vaccines. Here, we rationally engineer the sequence-conserved S2 subunit of the SARS-CoV-2 spike protein and characterize the resulting S2-only antigens.