Surl-Hee Ahn

Aug 26, 2024 | nature.com | Xandra Nuqui |Lorenzo Casalino |Ling Zhou |Albert Wang |Alexandra L. Tse |Surl-Hee Ahn | +1 more

AbstractThe full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodominant S1 subunit. S2, in contrast, is the most evolutionarily conserved region of the spike and can elicit broadly neutralizing and protective antibodies. Yet, S2’s usage as an alternative vaccine strategy is hampered by its general instability.