Ali Ebrahim

Feb 18, 2025 | biorxiv.org | Liliana Abarca Guerrero |Ali Ebrahim |Blake T. Riley |Sean Kim

AbstractProtein tyrosine phosphatases (PTPs) play pivotal roles in myriad cellular processes by counteracting protein tyrosine kinases. Striatal-enriched protein tyrosine phosphatase (STEP, PTPN5) regulates synaptic function and neuronal plasticity in the brain and is a therapeutic target for several neurological disorders. Here, we present three new crystal structures of STEP, each with unexpected features.