Ali Khoshouei

Oct 24, 2024 | science.org | Manojit M. Swamynathan |Christopher Frank |Ali Khoshouei |Dominik Schiwietz |Christopher Talbot Frank |Lara Weber | +8 more

Editor’s summaryProtein design methods have made rapid progress in recent years with the introduction of machine learning–based generative models. Frank et al. now debut an alternative method called relaxed sequence optimization that enables efficient and robust convergence toward optimal structures on the basis of iterative sequence evolution using gradient descent–based hallucination.