Ali Tfaily

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Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology - Nature Communications

Mar 31, 2024 | nature.com | Prateek Kumar |Brendan Tobin |Eric B. Dammer |Nicholas T. Seyfried |Ali Tfaily

AbstractDysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. We used cell-type-specific in-vivo biotinylation of proteins (CIBOP) coupled with mass spectrometry to obtain native-state PV-IN proteomes.

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