Nicholas T. Seyfried

1 month ago | nature.com | Justin Moore |Timothy Wu |Eric B. Dammer |Nicholas T. Seyfried

AbstractParkinson’s disease (PD) starts decades before symptoms appear, usually in the later decades of life, when age-related changes are occurring.

Mar 31, 2024 | nature.com | Prateek Kumar |Brendan Tobin |Eric B. Dammer |Nicholas T. Seyfried |Ali Tfaily

AbstractDysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. We used cell-type-specific in-vivo biotinylation of proteins (CIBOP) coupled with mass spectrometry to obtain native-state PV-IN proteomes.

Jan 10, 2024 | nature.com | Kenneth Wilson |Sudipta Bar |Eric B. Dammer |Joanna Bons |Grace Qi |Akos Gerencser | +6 more

AbstractDietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.