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Alicia M. Douglas

Featured in: Favicon cell.com

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  • CAR T cell therapies for diffuse midline glioma

    Aug 2, 2023 | cell.com | Bryce Thomas |Michelle Monje |Nicholas A. Vitanza |Alicia M. Douglas

    HighlightsThe lack of effective therapies for DMG stems from tumor location, complex molecular features, and immunosuppressive tumor immune microenvironment. CAR therapy can effectively elicit an immune response in immunologically cold diffuse midline glioma tumors. Locoregional infusions of CAR T cells minimize therapy related toxicities, promote proinflammatory immune engagement, and may reduce immunosuppressive responses.

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