Michelle Monje

May 15, 2024 | nature.com | Sean A. Yamada-Hunter |Brianna J. McIntosh |Frank Lin |Amaury Leruste |Zinaida Good |Calvin J Kuo | +6 more

AbstractAdoptively transferred T cells and agents designed to block the CD47–SIRPα axis are promising cancer therapeutics that activate distinct arms of the immune system1,2. Here we administered anti-CD47 antibodies in combination with adoptively transferred T cells with the goal of enhancing antitumour efficacy but observed abrogated therapeutic benefit due to rapid macrophage-mediated clearance of T cells expressing chimeric antigen receptors (CARs) or engineered T cell receptors.

May 8, 2024 | nature.com | Michael Weller |Michelle Monje

AbstractGliomas are primary brain tumours that are thought to develop from neural stem or progenitor cells that carry tumour-initiating genetic alterations. Based on microscopic appearance and molecular characteristics, they are classified according to the WHO classification of central nervous system (CNS) tumours and graded into CNS WHO grades 1–4 from a low to high grade of malignancy.

Oct 19, 2023 | nature.com | Michelle Monje

AbstractExperience sculpts brain structure and function. Activity-dependent modulation of the myelinated infrastructure of the nervous system has emerged as a dimension of adaptive change during childhood development and in adulthood. Myelination is a richly dynamic process, with neuronal activity regulating oligodendrocyte precursor cell proliferation, oligodendrogenesis and myelin structural changes in some axonal subtypes and in some regions of the nervous system.

Sep 25, 2023 | nature.com | Jon Klein |Rahul Dhodapkar |Peiwen Lu |Valter Silva Monteiro |Julio César Silva |Júlio Silva | +16 more

AbstractPost-acute infection syndromes may develop after acute viral disease1. Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome known as long COVID. Individuals with long COVID frequently report unremitting fatigue, post-exertional malaise, and a variety of cognitive and autonomic dysfunctions2,3,4. However, the biological processes that are associated with the development and persistence of these symptoms are unclear.

Aug 30, 2023 | cell.com | Michelle Monje

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