Alisa Kumbara

Mar 23, 2025 | biorxiv.org | Manuel Tognon |Andrea Betti |Lorenzo Ruggeri |Alisa Kumbara

AbstractTranscription Factors (TFs) are essential regulatory proteins that control the cellular transcriptional states by binding to specific DNA sequences known as Transcription Factor Binding Sites (TFBSs) or motifs. Accurate TFBS identification is crucial for unraveling regulatory mechanisms driving cellular dynamics. Over the years, various computational approaches have been developed to model TFBSs, with Position Weight Matrices (PWMs) being one of the most widely adopted methods.