Am Hubland

Dec 4, 2024 | dx.doi.org | Am Hubland

AbstractThe circadian clock and its output pathways play a pivotal role in optimizing daily processes. To obtain insights into how diverse rhythmic physiology and behaviors are orchestrated, we have generated a comprehensive connectivity map of an animal circadian clock using the Drosophila FlyWire brain connectome. Intriguingly, we identified additional dorsal clock neurons, thus showing that the Drosophila circadian network contains ~240 instead of 150 neurons.

May 3, 2024 | cell.com | Dimitrios Papadopoulos |Am Hubland |Stefanie Anh Ha |Daniel Fleischhauer

Highlights•The MYCN oncoprotein exists in mutually exclusive DNA- and RNA-bound states•The conserved MYCBoxI mediates MYCN RNA binding in vitro and in cells•MYCN facilitates RNA processing as part of the nuclear exosome targeting complex•MYCN RNA binding supports S phase progression and tumor cell stress resilienceSummaryThe MYCN oncoprotein binds active promoters in a heterodimer with its partner protein MAX.

Mar 22, 2024 | karger.com | Am Hubland

Reaching 95 years of age, George M. Martin died on December 17, 2022. His death was not only untimely but viewed within the frame of his career, certainly too early. After a long and impressive series of publications in which he developed many groundbreaking concepts, he had just set out to develop two novel lines of thought. Being born in New York, George Martin moved at the age of 19 to Alaska.

Jun 16, 2023 | pubs.aip.org | Universität Würzburg |Am Hubland

We now focus on the correction of the 1Q signal with respect to higher-order contributions using both 2D and PP data. In Fig. 7, we show 1Q transients from 2D (a) and PP (b) measurements, averaged over ν̄t (from 12 200 to 12 800 cm−1). In the case of 2D spectroscopy, the measurements of 220 and 15 nJ are already shown in Fig. 5(b). The transients extracted from a set of three PP measurements with 4I0 of 200 nJ are shown in Fig. 6(b).