Amel Aziba

Dec 6, 2024 | biorxiv.org | Leonie Uhl |Timothy J. Russell |Amel Aziba |Sinah Loebbert

AbstractIn response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition; the underlying mechanisms and their function are unknown. Here, we show that MYC re-localizes from its canonical location on DNA to RNA in response to the accumulation of intronic RNA. MYC binds RNA directly, which enhances its multimerization.