Amir Dehsarvi

Jan 2, 2024 | nature.com | Nicolai Franzmeier |Amir Dehsarvi |Anna Dewenter |Sebastian Roemer |Matthias Brendel |Alexis Moscoso | +2 more

AbstractIn Alzheimer’s disease, amyloid-beta (Aβ) triggers the trans-synaptic spread of tau pathology, and aberrant synaptic activity has been shown to promote tau spreading. Aβ induces aberrant synaptic activity, manifesting in increases in the presynaptic growth-associated protein 43 (GAP-43), which is closely involved in synaptic activity and plasticity.