Nicolai Franzmeier

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Articles

Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease - Nature Communications

Jan 2, 2024 | nature.com | Nicolai Franzmeier |Amir Dehsarvi |Anna Dewenter |Sebastian Roemer |Matthias Brendel |Alexis Moscoso | +2 more

AbstractIn Alzheimer’s disease, amyloid-beta (Aβ) triggers the trans-synaptic spread of tau pathology, and aberrant synaptic activity has been shown to promote tau spreading. Aβ induces aberrant synaptic activity, manifesting in increases in the presynaptic growth-associated protein 43 (GAP-43), which is closely involved in synaptic activity and plasticity.
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight - Nature Reviews Neuroscience

Aug 24, 2023 | nature.com | Nicolai Franzmeier |Dani S. Bassett |David Jones |Nick Corriveau-Lecavalier

AbstractNeurodegenerative diseases are the most common cause of dementia. Although their underlying molecular pathologies have been identified, there is substantial heterogeneity in the patterns of progressive brain alterations across and within these diseases.

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