Amir Mehrkar

Nov 19, 2024 | nature.com | Ruth Costello |Emily Herrett |Amir Mehrkar |Laurie Tomlinson |Christopher T. Rentsch

AbstractBiological evidence suggests ursodeoxycholic acid (UDCA)—a common treatment of cholestatic liver disease—may prevent severe COVID-19 outcomes. We aimed to compare the hazard of COVID-19 hospitalisation or death between UDCA users versus non-users in a population with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC).

Mar 11, 2024 | nature.com | Genevieve Cezard |Rochelle Knight |Yinghui Wei |Renin Toms |Alex Walker |Jon Massey | +8 more

AbstractInfection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population.