Amr El-Demerdash

Jan 25, 2024 | nature.com | Shingo Kikuchi |Martin Rejzek |Charlotte Owen |James Reed |Rajesh Misra |Amr El-Demerdash | +3 more

AbstractQS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean soapbark tree. It is a key component of human vaccines for shingles, malaria, coronavirus disease 2019 and others under development. The structure of QS-21 consists of a glycosylated triterpene scaffold coupled to a complex glycosylated 18-carbon acyl chain that is critical for immunostimulant activity.