Rajesh Misra

Jan 25, 2024 | nature.com | Shingo Kikuchi |Martin Rejzek |Charlotte Owen |James Reed |Rajesh Misra |Amr El-Demerdash | +3 more

AbstractQS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean soapbark tree. It is a key component of human vaccines for shingles, malaria, coronavirus disease 2019 and others under development. The structure of QS-21 consists of a glycosylated triterpene scaffold coupled to a complex glycosylated 18-carbon acyl chain that is critical for immunostimulant activity.

May 7, 2023 | frontiersin.org | Nanjing Forestry |Jiangsu province |Rajesh Misra

1 IntroductionAcylation is a common chemical reaction in living organisms that catalyzes a series of oxygenated and nitrogenous compounds to synthesize corresponding ester and amide products (Wang et al., 2022). The BAHD acyltransferase family is a group of proteins that acylate primary and specialized secondary metabolites in plants.