Amy Claxton

Nov 2, 2024 | nature.com | Amy Claxton |David P Walling |Leslie Citrome |Haiyuan Zhu |Andrew Miller |Stephen K. Brannan | +5 more

In the 5-week, randomized, double-blind, placebo-controlled EMERGENT-1 (NCT03697252), EMERGENT-2 (NCT04659161), and EMERGENT-3 (NCT04738123) trials, xanomeline and trospium chloride (formerly known as KarXT) significantly improved symptoms of schizophrenia and was generally well tolerated. We pooled data from the EMERGENT trials to further characterize the efficacy of xanomeline/trospium and provide sufficient statistical power to analyze responses in participant subgroups. In pooled analyses, xanomeline/trospium significantly improved Positive and Negative Syndrome Scale (PANSS) total score at week 5 versus placebo (least squares mean difference, –9.9; 95% confidence interval, –12.4, –7.3; p < 0.0001; Cohen’s d effect size, 0.65). PANSS subscale and Clinical Global Impression–Severity scores also improved significantly with xanomeline/trospium versus placebo. Subgroup analyses consistently favored xanomeline/trospium over placebo regardless of differences in participant age, sex, race, body mass index, and baseline PANSS total score. These results add to existing evidence demonstrating robust and reliable improvements in symptoms with xanomeline/trospium across a broad spectrum of people with schizophrenia.

Sep 15, 2023 | geekpost.net | Amy Claxton

Follow Free Leaugue PublishingAt Gen Con 2023, we had the pleasure of meeting the mind behind Dragonbane, a classic fantasy tabletop roleplaying game that has quickly become a favorite among enthusiasts. Tomas Harenstam, lead designer and co-founder/CEO has not only crafted a world of magic and adventure but has also brought a unique perspective to the realm of game design.