Andrew Miller

Nov 2, 2024 | nature.com | Amy Claxton |David P Walling |Leslie Citrome |Haiyuan Zhu |Andrew Miller |Stephen K. Brannan | +5 more

In the 5-week, randomized, double-blind, placebo-controlled EMERGENT-1 (NCT03697252), EMERGENT-2 (NCT04659161), and EMERGENT-3 (NCT04738123) trials, xanomeline and trospium chloride (formerly known as KarXT) significantly improved symptoms of schizophrenia and was generally well tolerated. We pooled data from the EMERGENT trials to further characterize the efficacy of xanomeline/trospium and provide sufficient statistical power to analyze responses in participant subgroups. In pooled analyses, xanomeline/trospium significantly improved Positive and Negative Syndrome Scale (PANSS) total score at week 5 versus placebo (least squares mean difference, –9.9; 95% confidence interval, –12.4, –7.3; p < 0.0001; Cohen’s d effect size, 0.65). PANSS subscale and Clinical Global Impression–Severity scores also improved significantly with xanomeline/trospium versus placebo. Subgroup analyses consistently favored xanomeline/trospium over placebo regardless of differences in participant age, sex, race, body mass index, and baseline PANSS total score. These results add to existing evidence demonstrating robust and reliable improvements in symptoms with xanomeline/trospium across a broad spectrum of people with schizophrenia.

Jun 24, 2024 | ajan.com.au | Andrew Miller |Craig Jones |Carole Pinnock

Main Article ContentAndrew W. Miller, BA (Hons)Craig E. Jones, BSc (Hons), Dip ITCarole B. Pinnock, PhDKeywordsevidence based practice, education AbstractAbstract 0 |view PDF Downloads 0Article SidebarArticle DetailsHow to Cite1. DIFFERENCES IN ACCESS TO EVIDENCE BASED PRACTICE TRAINING AMONG HEALTH PROFESSIONALS. Aust J Adv Nurs [Internet]. 2003 May 1 [cited 2024 Jun. 25];20(3).

May 22, 2024 | thestage.co.uk | Andrew Miller

Amy Trigg with her Olivier award for best supporting actress in a musical for The Little Big Things. Photo: Joanne DavidsonThe push for inclusivity in the arts is starting to bear fruit, with disabled-led work achieving well-deserved success, says Andrew Miller. So why is the idea that access and excellence can go hand in hand still not accepted by some? Support The Stage by registering or subscribingTo continue reading this article you must be logged in.

Feb 20, 2024 | thestage.co.uk | Andrew Miller

OpinionRalph Fiennes and Indira Varma in Macbeth at the Depot, Liverpool. Photo: Matt HumphreyThe debate about content warnings misses the fundamental point: they enable accessSupport The Stage by registering or subscribingTo continue reading this article you must be logged in. Register or login to unlock 3 free articles every month. OR Or, even better, subscribe for unlimited access and help support independent journalism from as little as £5.99. Remember Login

Jan 11, 2024 | msn.com | Andrew Miller