Ana Elena Lopez-Romero

Jul 2, 2024 | biorxiv.org | Miriam Huerta |Maria Luisa Guzman-Hernandez |Ana Elena Lopez-Romero |Rita Moran-Zendejas

AbstractThe Ca2+-dependent Cl- channel TMEM16A activity is vital for mammals. Critical functions such as blood pressure, pain, fluid and electrolyte secretion, peristalsis, and electrical activity depend on TMEM16A Cl- fluxes. Ciclosporin A (CsA) and FK506, two immunosuppressants that inhibit calcineurin (CaN), down-regulate TMEM16A function. However, the underlying mechanism remains undetermined.