Ana J. García-Sáez

Feb 29, 2024 | nature.com | Enyong Dai |Xin McRae Chen |Xuejun Jiang |Rui Kang |Valerian E. Kagan |Ana J. García-Sáez | +27 more

AbstractFerroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity.

Aug 10, 2023 | nature.com | Ana J. García-Sáez

The term “regulated cell death” encompasses a set of signaling pathways that have evolved to modulate the process of cellular demise in response to overwhelming stress or as part of a developmental program [1]. While certain primal cell death pathways have been identified in unicellular organisms as a form of altruism to stop infection spread in the community, it is in multicellular organisms that regulated cell death becomes central for life.