Xin McRae Chen

Oct 30, 2024 | bmcpsychology.biomedcentral.com | Xin McRae Chen |Lifu Jin |Yanhua Fan |Jian Wang

Although extant literature has investigated the impacts of social sites on employees’ job performance in different sectors, scholars have given little attention to teachers’ job performance (TJoP) in higher educational institutes. We aimed to investigate the direct and mediating impact of social media use (SMU) on TJoP. Based on social cognitive theory, this study proposed a model that consists of six hypotheses. : To empirically test the model, we develop a survey link to collect data from respondents working in universities in Jiangsu province, China. Partial least square structural equation modeling (PLS–SEM) using SmartPLS 4 has been used for analyzing 454 respondents. Research findings demonstrate the significant effects of SMU on TJoP, well-being, and social media addiction (SMAdd). In addition, teachers’ well-being and SMAdd have a positive and negative significant effect, respectively, on TJoP. Moreover, this research evidenced a significant partial mediation of teachers’ well-being and SMAdd. This study points out the key role of SMU in the direct and indirect influences of TJoP through well-being and SMAdd. Further, it brings into view the urgency of higher education to prudently consider the implications of SMU on performance and general well-being among its faculty.

Sep 30, 2024 | nature.com | Xin McRae Chen |Peng Cheng

AbstractGlycolytic metabolic reprogramming in cancer is regulated by both cancer intrinsic variations like isocitrate dehydrogenase 1 (IDH1) status and non-cancerous microenvironment components like tumor associated macrophages (TAMs). However, the detailed mechanism remains elusive. Here, we identify hexosaminidase B (HEXB) as a key regulator for glycolysis in glioblastoma (GBM).

Aug 3, 2024 | nature.com | Xin McRae Chen |Le Yu |Dailiang Peng |Xiaoling Zhang |Chuanglin Fang

AbstractChina prioritizes a coordinated and sustainable shift from rural to urban areas, termed rural-urban transformation. This involves land, population, and industry urbanization. Here we explore the spatiotemporal dynamics of rural-urban transformation patterns in China, focusing on the degree of integrated transformation and the coupling between the three tracks.

Feb 29, 2024 | nature.com | Enyong Dai |Xin McRae Chen |Xuejun Jiang |Rui Kang |Valerian E. Kagan |Ana J. García-Sáez | +27 more

AbstractFerroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity.

Jul 27, 2023 | nature.com | Diego F. Calvisi |Xin McRae Chen

AbstractHepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients show a poor prognosis. Importantly, we found that concomitant deletion of Trp53 and overexpression of c-MET (c-MET/sgp53) in the mouse liver led to HCC formation in vivo.