Ana-Maria Lennon-Duménil

Dec 10, 2024 | cell.com | Marianne Basso |Alexia Mahuzier |Syed Ali |Anaïs Marty |Marion Faucourt |Ana-Maria Lennon-Duménil | +8 more

Keywordsmulticiliatedependymal celldifferentiationactinnucleusmechanotransductioncell cycleMCIDASretinoblastomaLINC complexIntroductionMulticiliated ependymal cells (ECs) are located along brain ventricles. They form a protective barrier to the brain parenchyma and contribute to cerebrospinal fluid flow through the beating of their motile cilia.1 Impairment of this flow correlates with age-related dementia,2 schizophrenia,3 and hydrocephalus,4 diseases whose onset is not always understood.

Oct 15, 2023 | biorxiv.org | Alexia Mahuzier |Marianne Basso |Ana-Maria Lennon-Duménil |Marion Faucourt

AbstractEpendymal cells (ECs) are multi-ciliated cells in the brain that contribute to cerebrospinal fluid flow. ECs are specified at embryonic stages but differentiate and grow cilia later in development. Differentiation depends on genes such as GEMC1 and MCIDAS with E2F4/5 but also on cell cycle related factors. In the mouse brain, we observe that nuclear deformation accompanies EC differentiation.