Marion Faucourt

Dec 30, 2024 | cell.com | Jacques Serizay |Michella Khoury Damaa |Amelie-Rose Boudjema |Remi Balague |Marion Faucourt |Nathalie Delgehyr | +6 more

Keywordscell cycle variantcyclinsAPC/Ccentriolesingle-cell transcriptomicsmulticiliated cellsciliacancermeiosisciliopathiesResearch topic(s)CP: Cell biologyCP: Developmental biologyIntroductionShared factors regulate centriole and DNA duplication processes throughout the cell cycle, and centriole over-duplication is typically associated with genomic instability, accelerating tumor formation and increasing tumor invasiveness (review in Nigg and Holland1).

Dec 10, 2024 | cell.com | Marianne Basso |Alexia Mahuzier |Syed Ali |Anaïs Marty |Marion Faucourt |Ana-Maria Lennon-Duménil | +8 more

Keywordsmulticiliatedependymal celldifferentiationactinnucleusmechanotransductioncell cycleMCIDASretinoblastomaLINC complexIntroductionMulticiliated ependymal cells (ECs) are located along brain ventricles. They form a protective barrier to the brain parenchyma and contribute to cerebrospinal fluid flow through the beating of their motile cilia.1 Impairment of this flow correlates with age-related dementia,2 schizophrenia,3 and hydrocephalus,4 diseases whose onset is not always understood.

Oct 15, 2023 | biorxiv.org | Alexia Mahuzier |Marianne Basso |Ana-Maria Lennon-Duménil |Marion Faucourt

AbstractEpendymal cells (ECs) are multi-ciliated cells in the brain that contribute to cerebrospinal fluid flow. ECs are specified at embryonic stages but differentiate and grow cilia later in development. Differentiation depends on genes such as GEMC1 and MCIDAS with E2F4/5 but also on cell cycle related factors. In the mouse brain, we observe that nuclear deformation accompanies EC differentiation.