Ana Resende-Coelho

2 months ago | biorxiv.org | Mohsin Ali |Intawat Nookaew |Ana Resende-Coelho |Adriana Marques-Carvalho

AbstractMitochondrial (mt)ROS, insufficient NAD+, and cellular senescence all contribute to the decrease in bone formation with aging. ROS can cause senescence and decrease NAD+, but it remains unknown whether these mechanisms mediate the effects of ROS in vivo. Here, we generated mice lacking the mitochondrial antioxidant enzyme Sod2 in osteoblast lineage cells targeted by Osx1-Cre and showed that Sod2ΔOsx1 mice had low bone mass.

2 months ago | aging-us.com | Ana Resende-Coelho |Mohsin Ali |Alicen James |Aaron Warren

Research Paper Volume 17, Issue 3 pp 610—629 1 Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 2 Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 3 Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 4 Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, AR...

2 months ago | aging-us.com | Ana Resende-Coelho |Mohsin Ali |Alicen James |Aaron Warren

Research Paper Volume 17, Issue 3 pp 610—629 1 Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 2 Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 3 Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 4 Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, AR...