Intawat Nookaew

Mar 25, 2025 | biorxiv.org | Mohsin Ali |Intawat Nookaew |Ana Resende-Coelho |Adriana Marques-Carvalho

AbstractMitochondrial (mt)ROS, insufficient NAD+, and cellular senescence all contribute to the decrease in bone formation with aging. ROS can cause senescence and decrease NAD+, but it remains unknown whether these mechanisms mediate the effects of ROS in vivo. Here, we generated mice lacking the mitochondrial antioxidant enzyme Sod2 in osteoblast lineage cells targeted by Osx1-Cre and showed that Sod2ΔOsx1 mice had low bone mass.