Ananthan Sadagopan

Dec 18, 2023 | nature.com | Tuan Nguyen |Katherine A. Donovan |Santosh K. Chaudhary |Ananthan Sadagopan |David R. Liu |Benjamin Ebert

AbstractProteolysis-targeting chimeras (PROTACs) are molecules that induce proximity between target proteins and E3 ligases triggering target protein degradation. Pomalidomide, a widely used E3 ligase recruiter in PROTACs, can independently degrade other proteins, including zinc-finger (ZF) proteins, with vital roles in health and disease.