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2 months ago | 
pubs.acs.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan
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2 months ago | 
dx.doi.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan
Wednesday, January 29, 2025 Please be aware that pubs.acs.org is undergoing maintenance on Saturday, November 16, at 6 p.m. EDT that may have an impact on your experience. During this time, you may not be able to access certain features like login, purchasing single articles, saving searches or running existing saved searches, modifying your e-Alert preferences, or accessing Librarian administrative functions. We appreciate your patience as we continue to improve the ACS Publications platform.
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Nov 28, 2024 | 
mondaq.com | Katherine A. Donovan
A few recent patent applications reveal that the Honda Element
may be making its return to the automotive industry:
The first patent application is a “camper for a vehicle”.
The second patent application is for an “adjustable cargo area partition for a
vehicle”. Images filed alongside the patent applications
showcase a large box-styled vehicle with “a smaller rear door that appears to be
rear-hinged”.
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Oct 1, 2024 | 
biorxiv.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan
AbstractMolecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase thereby inducing target protein degradation. Glutarimide-containing compounds are MGDs that bind to cereblon (CRBN) and recruit neosubstrates. Through explorative synthesis of a glutarimide-based library, we discovered a series of molecules that induce casein kinase 1 alpha (CK1α) degradation.
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Sep 24, 2024 | 
mondaq.com | Katherine A. Donovan
Steve King, the former Iowa Republican Congressman, has
reportedly lost his appeal attempting to overturn a
copyright verdict for using the "Success Kid" meme in his
2020 campaign.
The "Success Kid meme" is the widely popular image of
Sammy Griner as a toddler pumping his fist with a determined face. His mother, Laney Griner, successfully licensed the "Success
Kid" picture to companies such as Coca-Cola and Microsoft,
giving the meme commercial value.
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Sep 5, 2024 | 
digitalcommons.library.tmc.edu | Wubing Zhang |Jiaye Chen |Katherine A. Donovan |Yang Cao
Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting by TPD approaches, termed “degradability”, is largely unknown. Here, we developed a machine learning model, model-free analysis of protein degradability (MAPD), to predict degradability from features intrinsic to protein targets.
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Sep 4, 2024 | 
mondaq.com | Katherine A. Donovan
A federal judge in California reportedly dismissed a lawsuit for breach-of-contract and
tort claims brought by Elon Musk's X, formerly known as
Twitter, against Bright Data, in a case involving data
scraping.
X reportedly alleged that Bright Data was taking data from its
platform and selling it, employing methods to evade X's
anti-scraping technology, and violating its terms of service and
copyright.
is the process of extracting large volumes of data
from publicly available web sources.
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Jul 28, 2024 | 
nature.com | Moritz Hunkeler |Mingxing Teng |Justine C. Rutter |Anna M Schmoker |Rebecca Metivier |Woong Sub Byun | +9 more
AbstractMolecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and expedite discovery. Here we unveil a trans-labeling covalent molecular glue mechanism, termed ‘template-assisted covalent modification’.
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Jul 19, 2024 | 
mondaq.com | Katherine A. Donovan
p
Boeing and
its subsidiary, Aurora Flight Sciences, are reportedly suing
Virgin Galactic, a space tourism start-up, for allegedly
misappropriating trade secrets and failing to pay $25 million for
work completed. Aurora was tasked by Virgin Galactic to complete
design work related to a "Mothership" project, but, due to
budgetary and timeline constraints, the project came to a
premature end.
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Jun 18, 2024 | 
nature.com | Han-Yuan Liu |Theresia Reindl |Ryan Golden |Katherine A. Donovan |Eric S. Fischer |Nathanael S. Gray
AbstractViral genetic diversity presents significant challenges in developing antivirals with broad-spectrum activity and high barriers to resistance. Here we report development of proteolysis targeting chimeras (PROTACs) targeting the dengue virus envelope (E) protein through coupling of known E fusion inhibitors to ligands of the CRL4CRBN E3 ubiquitin ligase.
